| Pair Name | Kaempferol, Verapamil | ||
| Phytochemical Name | Kaempferol (PubChem CID: 5280863 ) | ||
| Anticancer drug Name | Verapamil (PubChem CID: 2520 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Kaempferol, Verapamil | |||
| Disease Info | [ICD-11: 2C60] | Breast cancer | Investigative | |
| Biological Phenomena | Induction-->ROS generation | |||
| Gene Regulation | Up-regulation | Expression | MAP1LC3B | hsa81631 |
| Up-regulation | Expression | SQSTM1 | hsa8878 | |
| In Vitro Model | MDA-MB-231 | Breast adenocarcinoma | Homo sapiens (Human) | CVCL_0062 |
| MCF-7 | Invasive breast carcinoma of no special type | Homo sapiens (Human) | CVCL_0031 | |
| Result | Kaempferol with Verapamil impeded panoramic chemoevasion pathways in breast cancer through ROS overproduction and disruption of lysosomal biogenesis | |||
| Pair Name | Kaempferol, Verapamil | |||
| Disease Info | [ICD-11: 2C60] | Breast cancer | Investigative | |
| Biological Phenomena | Induction-->Blockade of cell cycle in G2/M phase | |||
| Gene Regulation | Down-regulation | Expression | ABCB1 | hsa5243 |
| Down-regulation | Expression | CD44 | hsa960 | |
| Down-regulation | Expression | NANOG | hsa79923 | |
| Down-regulation | Expression | POU5F1 | hsa5460 | |
| Down-regulation | Expression | SOX2 | hsa6657 | |
| In Vitro Model | MDA-MB-231 | Breast adenocarcinoma | Homo sapiens (Human) | CVCL_0062 |
| Result | Deregulation of the CD44-NANOG-MDR1 associated chemoresistance pathways of breast cancer stem cells potentiates the anti-cancer effect of Kaempferol in synergism with Verapamil | |||
| No. | Title | Href |
|---|---|---|
| 1 | Kaempferol with Verapamil impeded panoramic chemoevasion pathways in breast cancer through ROS overproduction and disruption of lysosomal biogenesis. Phytomedicine. 2023 May;113:154689. doi: 10.1016/j.phymed.2023.154689. | Click |
| 2 | Deregulation of the CD44-NANOG-MDR1 associated chemoresistance pathways of breast cancer stem cells potentiates the anti-cancer effect of Kaempferol in synergism with Verapamil. Toxicol Appl Pharmacol. 2022 Feb 15;437:115887. doi: 10.1016/j.taap.2022.115887. | Click |
